In response to the best game for PSone of all time, I am making a thread for what you feel is the best game for Nintendo of all time from NES to the Wii, any game. You can have one for each console, or multiple ones for one console.

NES: Kung Fu
Snes: Super Mario Bros 3
N64: The Legend of Zelda Ocarina of Time/ Super Smash Bros.
Gamecube: Super Smash Bros. Melee
Wii: Super Smash Bros. Brawl
Gameboy: ? I can't say, never owned one.
Gameboy Pocket: ?
Gameboy Color: ?
Gameboy Advance: Metroid: Zero Mission
Nintendo DS: All the mario games

Wii: Super Smash Bros. Brawl
GameCube: Super Smash Bros. Melee (I didn't play many GC games).
N64: GoldenEye 64
Game Boy Color: Pokemon Yellow
Game Boy: Pokemon Red
SNES: Super Mario All-Stars
NES: Duck Hunt

As for the DS, not sure. I like various games but none of them really stand out.

You loved that Duck Hunt eh GaMeR?
It was a great game. And quite a leap in technology with the zapper.

Nintendo DS: LoZ: The Phantom Hourglass
Wii: SSBBrawl
Nintendo 64: a Tie Between Super Mario 64 and LoZ: Majoras Mask

Gameboy color: Pokemon gold
Gameboy sp : pokemon ruby
Nintendo DS : Nintendogs ( stopped playing it for about a year ago....poor puppies)
Nintendo 64 : Legend of Zelda : ocarina of time / SSB
Nintendo gamecube : SSB Melee
Nintendo wii: SSBB

Im a Nintendo fan boy 8)

why does everyone think SSB Meele was the best game on Gamecube?
IMO Wind waker and Metal Gear was way better. and dont forget Mario Kart Double Dash

Let's see...This should be fun...

NES:
Bionic Commando
Little Nemo: The Dreammaster
Mario 3

SNES:
Mario Kart
Donkey Kong Country
Mario World

N64:
WWF No Mercy
Tony Hawk Pro Skater

Nice pick with WWF No Mercy there. Most all WWE games are solid gold. Except a couple.

NES-Super Tecmo Bowl (Tecmo Bowl close second)
SNES-Super Tecmo Bowl (Star Wars games were awesome too)
N64-Mario Kart

The Ocarina of Time... nuff said.